The weeks shown in color represent the start and end points of chemical exposure for each study.
|Study Results||Study Details||References|
Results for Dioxin (TCDD)Increased serum thyroid-stimulating hormone (TSH) with no change in T3 or T4
Subjects: Long-Evans rats
Chemical: Dioxin (TCDD)
Low doses tested: 1.0 μg/kg
Route of administration: dissolved in corn oil and delivered through gavage
Exposure duration: post-natal day 5 – single dose (comparable to human prenatal development from approximately day 1 of week 25 to day 1 of week 26)
Age of measurement: 25 days of age
|Reference [PubMed Link]
Fenton SE, Hamm JT, Birnbaum LS, Youngblood GL. 2002. Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Sci 67(1):63-74.