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4 results for: Chlorpyrifos, Spinal Cord and Hindbrain — WEEK 3

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Chlorpyrifos

Increased 5HT receptor (type 1A) binding in the brainstem at 1 and 2 mg/kg; increased 5HTT (serotonin transporter), 5HT (type 1A) and 5HT (type2) binding in the brainstem at 5 mg/kg

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0 or 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 9 – gestational day 12 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 5)

Age of measurement: gestational day 17 and 21

 Reference [PubMed Link]
Aldridge JE, Seidler FJ, Meyer A, Thillai I, Slotkin TA. 2003. Serotonergic systems targeted by developmental exposure to chlorpyrifos: Effects during different critical periods. Environ Health Perspect 111(14):1736-1743.
Study Results Study Details References

Results for Chlorpyrifos

Increased 5HTT (serotonin transporter), 5HT (type 1A) and 5HT (type2) binding over all brain regions studied at 1 and 5 mg/kg

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0 or 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 9 – gestational day 12 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 5)

Age of measurement: 60 days of age

 Reference [PubMed Link]
Aldridge JE, Seidler FJ, Slotkin TA. 2004. Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: Critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ Health Perspect 112(2):148-155.
Study Results Study Details References

Results for Chlorpyrifos

Increased activity of adelylyl cyclase in response to isproterenol, forskolin and Mn2+ in the brainstem and cerebellum at 5 mg/kg

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0 or 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 9 – gestational day 12 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 5)

Age of measurement: 60 days of age

 Reference [PubMed Link]
Meyer A, Seidler FJ, Aldridge JE, Tate CA, Cousins MM, Slotkin TA. 2004. Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure. Environ Health Perspect 112(3):295-301.
Study Results Study Details References

Results for Chlorpyrifos

Decreased protein/DNA ratio in the brainstem at 2 mg/kg

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0, 2.0 or 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 9 – gestational day 12 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 5)

Age of measurement: gestational days 17 and 21

 Reference [PubMed Link]
Qiao D, Seidler FJ, Padilla S, Slotkin TA. 2002. Developmental neurotoxicity of chlorpyrifos: What is the vulnerable period? Environ Health Perspect 110(11):1097-1103.